Evaluation of medicinal plants from Central Kalimantan for antimelanogenesis

TitleEvaluation of medicinal plants from Central Kalimantan for antimelanogenesis
Publication TypeJournal Article
Year of Publication2009
AuthorsArung ET, Kusuma IW, Christy EO, Shimizu K, Kondo R
JournalJournal of Natural Medicines
Volume63
Pagination473-480
Date PublishedOct
Type of ArticleArticle
ISBN Number1340-3443
Accession NumberISI:000269928000016
KeywordsARTOCARPUS-HETEROPHYLLUS, B16 melanoma, BIOSYNTHESIS, cell, CENTRAL KALIMANTAN, DPPH, GRAPE SEEDS, HERBAL MEDICINES, HUMAN, IDENTIFICATION, INHIBITION, Melanin, MELANOCYTES, MELANOGENESIS, MELANOMA-CELLS, MUSHROOM TYROSINASE, Traditional medicine, Tyrosinase inhibition
Abstract

In the course of searching for new materials to use as whitening agents, we screened 19 methanol extracts prepared from 14 medicinal plants from Central Kalimantan province, Indonesia. The screening methods used were the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay, a tyrosinase inhibition assay, and a melanin formation inhibition assay using B16 melanoma cells. The extracts of Willughbeia coriacea (bark part of aerial root), Phyllanthus urinaria (root), Eleutherine palmifolia (bulb), Eusideroxylon zwageri (seed), Dendrophthoe petandra (aerial root), Passiflora foetida (stem), and Vitex pinnata (root) showed DPPH radical-scavenging activity of more than 70% at 100 A mu g/ml. The extracts of W. coriacea (bark part of aerial root), P. urinaria (root), and D. petandra (aerial root) showed tyrosinase inhibitory activity of more than 40% using l-tyrosine as a substrate at 500 A mu g/ml. The extracts of W. coriacea (bark part of aerial root) and D. petandra (aerial root) showed tyrosinase inhibitory activity of more than 40% using l-DOPA as a substrate at 500 A mu g/ml. The extracts of W. coriacea (bark part of aerial root, 200 A mu g/ml), Glochidion philippcum (aerial root, 200 and 300 A mu g/ml), E. palmifolia (bulb, 50 A mu g/ml), E. zwageri (seed, 100 A mu g/ml), D. petandra (aerial root, 200 A mu g/ml), Lansium domesticum (bark, 25 A mu g/ml), P. foetida (stem, fruit, 300 A mu g/ml), and Solanum torvum (root, 300 A mu g/ml) strongly inhibited the melanin production of B16 melanoma cells without significant cytotoxicity. These findings indicate that some medicinal plants from Central Kalimantan are potential ingredients for skin-whitening cosmetics if their safety can be confirmed.

URL<Go to ISI>://000269928000016
Alternate JournalJ. Nat. Med.